All-trans retinoic acid induces oxidative phosphorylation and mitochondria biogenesis in adipocytes Running title: ATRA impacts mitochondrial function
نویسندگان
چکیده
1 INRA, UMR 1260, F-13385, Marseille, France. 2 INSERM, UMR 1062, « Nutrition, Obésité et Risque Thrombotique », F-13385, Marseille, France. 3 Aix-Marseille Université, Faculté de Médecine, F-13385, Marseille, France 4 Assistance Publique Hôpitaux de Marseille, CHU La Timone, F-13385, Marseille, France 5 Laboratory of Molecular Biology, Nutrition and Biotechnology/Nutrigenomics-group, Universitat de les
منابع مشابه
All-trans retinoic acid induces oxidative phosphorylation and mitochondria biogenesis in adipocytes.
A positive effect of all-trans retinoic acid (ATRA) on white adipose tissue (WAT) oxidative and thermogenic capacity has been described and linked to an in vivo fat-lowering effect of ATRA in mice. However, little is known about the effects of ATRA on mitochondria in white fat. Our objective has been to characterize the effect of ATRA on mitochondria biogenesis and oxidative phosphorylation (OX...
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We investigated the effects of retinoic acids on mitochondrial permeability transition (MPT) measured as changes in rhodamine 123 fluorescence from both isolated heart mitochondria and HeLa cells. We report that all-trans-retinoic acid (atRA), 9-cis-retinoic acid, and 13-cis-retinoic acid induce a drop in mitochondrial membrane potential in isolated mitochondria. The atRA effect was done throug...
متن کاملمروری بر نقش محافظتی ترکیبات پلی فنلی (رسوراترول، کوئرسیتین و کورکومین) بر عملکرد میتوکندری قلب
Mitochondria plays a major role in maintaining homeostasis of heart cells. Mitochondria produce ATP and is the main intracellular source of reactive oxygen species (ROS) which can cause oxidative damage. Free oxygen radicals and oxidative damage are associated with cardiovascular pathology. Antioxidant defense can play an essential role in preventing oxidative damage by controlling free oxygen ...
متن کاملAll-trans retinoic acid (atRA) differentially induces apoptosis in matched primary and metastatic melanoma cells -- a speculation on damage effect of atRA via mitochondrial dysfunction and cell cycle redistribution.
All-trans retinoic acid (atRA) has been suggested to exert its cytotoxicity via apoptosis but the mechanisms behind the damage effects have not been fully understood. In this study, we investigated the cytotoxic effects of atRA in eleven primary and matched metastatic cutaneous melanoma cell lines. All the primary and metastatic melanoma cell lines examined expressed the retinoic acid receptors...
متن کاملAll-Trans-Retinoic Acid Enhances Mitochondrial Function in Models of Human Liver.
All-trans-retinoic acid (atRA) is the active metabolite of vitamin A. The liver is the main storage organ of vitamin A, but activation of the retinoic acid receptors (RARs) in mouse liver and in human liver cell lines has also been shown. AlthoughatRA treatment improves mitochondrial function in skeletal muscle in rodents, its role in modulating mitochondrial function in the liver is controvers...
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